Mass treatment to eliminate tuberculosis from an island population
Identifieur interne : 004066 ( Main/Exploration ); précédent : 004065; suivant : 004067Mass treatment to eliminate tuberculosis from an island population
Auteurs : P. C. Hill [Nouvelle-Zélande] ; C. Dye [Suisse] ; K. Viney ; K. Tabutoa [Suisse, Kiribati] ; T. Kienene [Kiribati] ; K. Bissell [France, Nouvelle-Zélande] ; B. G. Williams [Afrique du Sud] ; R. Zachariah [Belgique] ; B. J. Marais [Australie] ; A. D. Harries [France, Royaume-Uni]Source :
- The International journal of tuberculosis and lung disease [ 1027-3719 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
SETTING: The global target of tuberculosis (TB) elimination by 2050 requires new approaches. Active case finding plus mass prophylactic treatment has been disappointing. We consider mass full anti-tuberculosis treatment as an approach to TB elimination in Kiribati, a Pacific Island nation, with a persistent epidemic of high TB incidence. OBJECTIVE: To construct a mathematical model to predict whether mass treatment with a full course of anti-tuberculosis drugs might eliminate TB from the defined population of the Republic of Kiribati. METHODS: We constructed a seven-state compartmental model of the life cycle of Mycobacterium tuberculosis in which active TB disease arises from the progression of infection, reinfection, reactivation and relapse, while distinguishing infectious from non-infectious disease. We evaluated the effects of 5-yearly mass treatment using a range of parameter values to generate outcomes in uncertainty analysis. RESULTS: Assuming population-wide treatment effectiveness for latent tuberculous infection and active TB of ≥90%, annual TB incidence is expected to fall sharply at each 5-yearly round of treatment, approaching elimination in two decades. The model showed that the incidence rate is sensitive to the relapse rate after successful treatment of TB. CONCLUSION: Mass treatment may help to eliminate TB, at least for discrete or geographically isolated populations.
Affiliations:
- Afrique du Sud, Australie, Belgique, France, Kiribati, Nouvelle-Zélande, Royaume-Uni, Suisse
- Angleterre, Grand Londres, Nouvelle-Galles du Sud, Île-de-France
- Londres, Paris, Sydney
- Université de Sydney
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Dye</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>HIV/AIDS, Tuberculosis, Malaria & Neglected Tropical Diseases Cluster, World Health Organization</s1><s2>Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Viney, K" sort="Viney, K" uniqKey="Viney K" first="K." last="Viney">K. Viney</name><affiliation><inist:fA14 i1="03"><s1>Public Health Division, Secretariat of the Pacific Community</s1><s2>Noumea</s2><s3>NCL</s3><sZ>3 aut.</sZ></inist:fA14><wicri:noCountry>NCL</wicri:noCountry></affiliation></author><author><name sortKey="Tabutoa, K" sort="Tabutoa, K" uniqKey="Tabutoa K" first="K." last="Tabutoa">K. Tabutoa</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>HIV/AIDS, Tuberculosis, Malaria & Neglected Tropical Diseases Cluster, World Health Organization</s1><s2>Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Tuberculosis Control Programme, Ministry of Health and Medical Services</s1><s3>KIR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Kiribati</country><wicri:noRegion>National Tuberculosis Control Programme, Ministry of Health and Medical Services</wicri:noRegion></affiliation></author><author><name sortKey="Kienene, T" sort="Kienene, T" uniqKey="Kienene T" first="T." last="Kienene">T. Kienene</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Tuberculosis Control Programme, Ministry of Health and Medical Services</s1><s3>KIR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Kiribati</country><wicri:noRegion>National Tuberculosis Control Programme, Ministry of Health and Medical Services</wicri:noRegion></affiliation></author><author><name sortKey="Bissell, K" sort="Bissell, K" uniqKey="Bissell K" first="K." last="Bissell">K. Bissell</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>International Union Against Tuberculosis and Lung Disease</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>School of Population Health, University of Auckland</s1><s2>Auckland</s2><s3>NZL</s3><sZ>6 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Williams, B G" sort="Williams, B G" uniqKey="Williams B" first="B. G." last="Williams">B. G. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>South African Centre for Epidemiological Modelling and Analysis</s1><s2>Cape Town</s2><s3>ZAF</s3><sZ>7 aut.</sZ></inist:fA14><country>Afrique du Sud</country><wicri:noRegion>South African Centre for Epidemiological Modelling and Analysis</wicri:noRegion></affiliation></author><author><name sortKey="Zachariah, R" sort="Zachariah, R" uniqKey="Zachariah R" first="R." last="Zachariah">R. Zachariah</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Médecins Sans Frontières, Brussels Operational Centre</s1><s2>Luxembourg</s2><s3>BEL</s3><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Marais, B J" sort="Marais, B J" uniqKey="Marais B" first="B. J." last="Marais">B. J. Marais</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Sydney Emerging Infectious Disease and Biosecurity Institute and Centre for Research Excellence in Tuberculosis, University of Sydney</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Harries, A D" sort="Harries, A D" uniqKey="Harries A" first="A. D." last="Harries">A. D. Harries</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>International Union Against Tuberculosis and Lung Disease</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>London School of Hygiene & Tropical Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0196387</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0196387 INIST</idno><idno type="RBID">Pascal:14-0196387</idno><idno type="wicri:Area/PascalFrancis/Corpus">000309</idno><idno type="wicri:Area/PascalFrancis/Curation">005B53</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000203</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000203</idno><idno type="wicri:doubleKey">1027-3719:2014:Hill P:mass:treatment:to</idno><idno type="wicri:Area/Main/Merge">004127</idno><idno type="wicri:Area/Main/Curation">004066</idno><idno type="wicri:Area/Main/Exploration">004066</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Mass treatment to eliminate tuberculosis from an island population</title><author><name sortKey="Hill, P C" sort="Hill, P C" uniqKey="Hill P" first="P. C." last="Hill">P. C. Hill</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Centre for International Health, Department of Preventive and Social Medicine, Faculty of Medicine, University of Otago</s1><s2>Dunedin</s2><s3>NZL</s3><sZ>1 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Dunedin</wicri:noRegion></affiliation></author><author><name sortKey="Dye, C" sort="Dye, C" uniqKey="Dye C" first="C." last="Dye">C. Dye</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>HIV/AIDS, Tuberculosis, Malaria & Neglected Tropical Diseases Cluster, World Health Organization</s1><s2>Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Viney, K" sort="Viney, K" uniqKey="Viney K" first="K." last="Viney">K. Viney</name><affiliation><inist:fA14 i1="03"><s1>Public Health Division, Secretariat of the Pacific Community</s1><s2>Noumea</s2><s3>NCL</s3><sZ>3 aut.</sZ></inist:fA14><wicri:noCountry>NCL</wicri:noCountry></affiliation></author><author><name sortKey="Tabutoa, K" sort="Tabutoa, K" uniqKey="Tabutoa K" first="K." last="Tabutoa">K. Tabutoa</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>HIV/AIDS, Tuberculosis, Malaria & Neglected Tropical Diseases Cluster, World Health Organization</s1><s2>Geneva</s2><s3>CHE</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Geneva</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Tuberculosis Control Programme, Ministry of Health and Medical Services</s1><s3>KIR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Kiribati</country><wicri:noRegion>National Tuberculosis Control Programme, Ministry of Health and Medical Services</wicri:noRegion></affiliation></author><author><name sortKey="Kienene, T" sort="Kienene, T" uniqKey="Kienene T" first="T." last="Kienene">T. Kienene</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Tuberculosis Control Programme, Ministry of Health and Medical Services</s1><s3>KIR</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Kiribati</country><wicri:noRegion>National Tuberculosis Control Programme, Ministry of Health and Medical Services</wicri:noRegion></affiliation></author><author><name sortKey="Bissell, K" sort="Bissell, K" uniqKey="Bissell K" first="K." last="Bissell">K. Bissell</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>International Union Against Tuberculosis and Lung Disease</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>School of Population Health, University of Auckland</s1><s2>Auckland</s2><s3>NZL</s3><sZ>6 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Williams, B G" sort="Williams, B G" uniqKey="Williams B" first="B. G." last="Williams">B. G. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>South African Centre for Epidemiological Modelling and Analysis</s1><s2>Cape Town</s2><s3>ZAF</s3><sZ>7 aut.</sZ></inist:fA14><country>Afrique du Sud</country><wicri:noRegion>South African Centre for Epidemiological Modelling and Analysis</wicri:noRegion></affiliation></author><author><name sortKey="Zachariah, R" sort="Zachariah, R" uniqKey="Zachariah R" first="R." last="Zachariah">R. Zachariah</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Médecins Sans Frontières, Brussels Operational Centre</s1><s2>Luxembourg</s2><s3>BEL</s3><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Luxembourg</wicri:noRegion></affiliation></author><author><name sortKey="Marais, B J" sort="Marais, B J" uniqKey="Marais B" first="B. J." last="Marais">B. J. Marais</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Sydney Emerging Infectious Disease and Biosecurity Institute and Centre for Research Excellence in Tuberculosis, University of Sydney</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Harries, A D" sort="Harries, A D" uniqKey="Harries A" first="A. D." last="Harries">A. D. Harries</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>International Union Against Tuberculosis and Lung Disease</s1><s2>Paris</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>London School of Hygiene & Tropical Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>10 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j" type="main">The International journal of tuberculosis and lung disease</title><title level="j" type="abbreviated">Int. j. tuberc. lung dis.</title><idno type="ISSN">1027-3719</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The International journal of tuberculosis and lung disease</title><title level="j" type="abbreviated">Int. j. tuberc. lung dis.</title><idno type="ISSN">1027-3719</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Elimination</term><term>Human</term><term>Island</term><term>Mass campaign</term><term>Population</term><term>Respiratory disease</term><term>Treatment</term><term>Tuberculosis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tuberculose</term><term>Pathologie de l'appareil respiratoire</term><term>Campagne de masse</term><term>Traitement</term><term>Ile</term><term>Homme</term><term>Population</term><term>Elimination</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SETTING: The global target of tuberculosis (TB) elimination by 2050 requires new approaches. Active case finding plus mass prophylactic treatment has been disappointing. We consider mass full anti-tuberculosis treatment as an approach to TB elimination in Kiribati, a Pacific Island nation, with a persistent epidemic of high TB incidence. OBJECTIVE: To construct a mathematical model to predict whether mass treatment with a full course of anti-tuberculosis drugs might eliminate TB from the defined population of the Republic of Kiribati. METHODS: We constructed a seven-state compartmental model of the life cycle of Mycobacterium tuberculosis in which active TB disease arises from the progression of infection, reinfection, reactivation and relapse, while distinguishing infectious from non-infectious disease. We evaluated the effects of 5-yearly mass treatment using a range of parameter values to generate outcomes in uncertainty analysis. RESULTS: Assuming population-wide treatment effectiveness for latent tuberculous infection and active TB of ≥90%, annual TB incidence is expected to fall sharply at each 5-yearly round of treatment, approaching elimination in two decades. The model showed that the incidence rate is sensitive to the relapse rate after successful treatment of TB. CONCLUSION: Mass treatment may help to eliminate TB, at least for discrete or geographically isolated populations.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Australie</li><li>Belgique</li><li>France</li><li>Kiribati</li><li>Nouvelle-Zélande</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><noCountry><name sortKey="Viney, K" sort="Viney, K" uniqKey="Viney K" first="K." last="Viney">K. Viney</name></noCountry><country name="Nouvelle-Zélande"><noRegion><name sortKey="Hill, P C" sort="Hill, P C" uniqKey="Hill P" first="P. C." last="Hill">P. C. Hill</name></noRegion><name sortKey="Bissell, K" sort="Bissell, K" uniqKey="Bissell K" first="K." last="Bissell">K. Bissell</name></country><country name="Suisse"><noRegion><name sortKey="Dye, C" sort="Dye, C" uniqKey="Dye C" first="C." last="Dye">C. Dye</name></noRegion><name sortKey="Tabutoa, K" sort="Tabutoa, K" uniqKey="Tabutoa K" first="K." last="Tabutoa">K. Tabutoa</name></country><country name="Kiribati"><noRegion><name sortKey="Tabutoa, K" sort="Tabutoa, K" uniqKey="Tabutoa K" first="K." last="Tabutoa">K. Tabutoa</name></noRegion><name sortKey="Kienene, T" sort="Kienene, T" uniqKey="Kienene T" first="T." last="Kienene">T. Kienene</name></country><country name="France"><region name="Île-de-France"><name sortKey="Bissell, K" sort="Bissell, K" uniqKey="Bissell K" first="K." last="Bissell">K. Bissell</name></region><name sortKey="Harries, A D" sort="Harries, A D" uniqKey="Harries A" first="A. D." last="Harries">A. D. Harries</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Williams, B G" sort="Williams, B G" uniqKey="Williams B" first="B. G." last="Williams">B. G. Williams</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Zachariah, R" sort="Zachariah, R" uniqKey="Zachariah R" first="R." last="Zachariah">R. Zachariah</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Marais, B J" sort="Marais, B J" uniqKey="Marais B" first="B. J." last="Marais">B. J. Marais</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Harries, A D" sort="Harries, A D" uniqKey="Harries A" first="A. D." last="Harries">A. D. Harries</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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